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Shid, S. J.
- Preparation and Evaluation of Fast Dissolving Tablet Tramadol Hydrochloride
Authors
1 Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa, Dist-Satara, IN
Source
Asian Journal of Pharmacy and Technology, Vol 6, No 3 (2016), Pagination: 183-185Abstract
Novel drug delivery system assists to achieve better patient compliance. Fast dissolving tablets are one of them. FDT have benefits such as accurate dosing, easy portability and manufacturing, good physical and chemical stability and an ideal alternative for pediatric and geriatric patients. FDDT formulation combines the advantage of both liquid and conventional tablet formulation while also offering advantage over both traditional dosage forms. This review gives a view of advantages, limitations, need for formulating FDTS, Formulation factors, excipients used, and methodology and evaluation parameters.
Fast dissolving tablets (FDTs) can be prepared by different methods, such as direct compression, freeze-drying, spray drying, sublimation, wet granulation method4. The basic approach for the development of FDTs is the use of superdisintegrants. The aim of this study was to formulate FDTs with sufficient mechanical integrity and to achieve faster disintegration in the oral cavity without water. To achieve this goal, mannitol used as diluent as well as sweetening agent for the formulation of tablets. Attempts were made to enhance dissolution rate along with faster disintegration using superdisintegrants, like microcrystalline cellulose. Tramadol hydrochloride, a centrally acting synthetic opioid analgesic, was selected as the active pharmaceutical ingredient in the study.
Keywords
Tramadol Hydrochloride, Direct Compression Method, Microcrystalline Cellulose.- Formulation and Optimization of Dermatological Dosage form for Comparative in-vitro Evaluation of Semisolid Bases
Authors
1 Rajarambapu College of Pharmacy, Kasegaon, Tal- Walwa, Dist-Sangli, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 7, No 2 (2016), Pagination: 46-54Abstract
The aim of this study was to improve the permeation of Diclofenac Sodium. Permeation studies were carried out in - vitro using cellophane membrane. Topical formulations of diclofenac sodium were prepared by using various polymers. Gel, cream and ointment of the drug were prepared with polymers and the formulations were subjected for evaluation. Gel formulations were containing carbopol 940, triethanolamine, and preservatives. Cream was formulated by using stearic acid, glycerin, lanolin and preservatives. Ointment was also formulated by using the ingredients cetostearyl alcohol, hard paraffin, white soft paraffin and wool fat. In-vitro permeation studies by using cellophane membrane in diffusion cell revealed better permeation characteristics of diclofenac sodium. These types of topical dosage forms could give sustained delivery of drug on to the skin, so they are interesting promises to improve skin absorption of non steroidal anti-inflammatory drugs and to prevent side effects associated. The Topical formulations are excellent in the percutaneous absorption of diclofenac or its salts and provide good properties upon use and superior medical effects of diclofenac or its salts.Keywords
Diclofenac Sodium, Gel, Cream, Ointment, Diffusion Cell.- A Review on Breast Cancer:An Overview
Authors
1 Rajarambapu College of Pharmacy, Kasegaon Sangli-415404, IN
Source
Asian Journal of Pharmaceutical Research, Vol 7, No 1 (2017), Pagination: 49-51Abstract
Each year more than one million women are diagnosed with breast cancer worldwide over half of whom will die from the disease. Breast cancer is the most common cancer and the leading cause of cancer death for women. Extensive breast cancer screening programmes and the development of new treatments have improved the prognosis of breast cancer overall. However the average year survival rate for women with late stage or advanced breast cancer remains low. On average only 35% of women with advanced breast cancer are alive five years after diagnosis. A third of women are diagnosed with breast cancer at a late stage4 when the disease has a poor prognosis. Treatment options for breast cancer vary depending on the stage at which the cancer is diagnosed. Surgery and radiotherapy are commonly used to treat women with early stage breast cancer. Chemotherapy, hormonal and targeted therapies are frequently used to treat patients with more advanced forms of the disease.Keywords
Breast Cancer, Abnormal Cells, Stages, Diagnosis, Etc.- Formulation and Evaluation of Polyherbal Anti-Acne Gel
Authors
1 Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa, Dist-Satara, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 8, No 2 (2017), Pagination: 61-63Abstract
Acne is an infection of the skin, caused by changes in the sebaceous glands. The most common form of acne is called acne vulgaris, which means "common acne". The redness comes from the inflammation of the skin in response to the infection. One of the most common disorders found among youngsters usually 18-25 years of age is Acne. Acne vulgaris, which is a skin disorder of the pilosebaceous gland leads to the formation of inflammatory lesions, seborrhea etc. There is a remarkable demand of herbal formulations in the global market. Acne is a popular disorder among the teenagers which make them feel unappealing to look at and also a sort of inferior feel. They take many measures to avoid and cure acne. Plants are well known for their medicinal and cosmetic uses.Keywords
Acne, Neem, Nutmeg.References
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